Developmental and extracellular matrix-remodeling processes in rosiglitazone-exposed neonatal rat cardiomyocytes
نویسندگان
چکیده
منابع مشابه
p38 MAP kinase mediates inflammatory cytokine induction in cardiomyocytes and extracellular matrix remodeling in heart.
BACKGROUND Increasing evidence suggests that development of heart failure involves activation of stress-response inflammatory cytokines, including tumor necrosis factor-alpha and interleukin-6. Yet, the myocyte contribution to their induction in failing hearts and the underlying regulatory mechanism in stressed myocardium remain unclear. METHODS AND RESULTS In cultured cardiac myocytes, speci...
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Increases in arterial blood pressure cause cumulative changes in tissue structure and function, resulting ultimately in end-organ damage. One of the pathological hallmarks of hypertensive tissue injury is an increase in tissue fibrosis, which leads to reductions in tissue compliance and function. Fibrosis (or sclerosis) occurs as result of marked changes in the amount and composition of the ext...
متن کاملDevelopmental expression of myostatin in cardiomyocytes and its effect on foetal and neonatal rat cardiomyocyte proliferation.
OBJECTIVES Myostatin, a member of the transforming growth factor-beta (TGF-beta) family, plays a key role in skeletal muscle myogenesis by limiting hyperplastic and hypertrophic muscle growth. In cardiac muscle, myostatin has been shown to limit agonist-induced cardiac hypertrophic growth. However, its role in cardiac hyperplastic growth remains undetermined. The aim of this study was to charac...
متن کاملExtracellular matrix remodeling in hypertensive heart disease.
everal decades ago, the severity of heart failure was gauged ccording to a depression in myocardial contractility, dened as that biochemical property of cardiac muscle that etermines the extent of shortening independent of its nitial length and the load against which it shortens. athematical models were used to derive indices of conractility (1). These theoretical constructs included a conracti...
متن کاملKetamine Inhibits Inositol 1,4,5-Trisphosphate Production Depending on the Extracellular Ca Concentration in Neonatal Rat Cardiomyocytes
We investigated the effect of ketamine on inositol 1,4,5trisphosphate (IP3) formation in rat cardiomyocytes. After the addition of 1 mmol/L ketamine, IP3 production in the presence of 0.5, 1, 5, 10, and 30 mmol/L Ca significantly decreased from 537.1 6 8.3, 590.7 6 12.9, 690.6 6 7.9, 754.8 6 12.5, and 823.7 6 15.2 pmol/mg protein to 467.0 6 8.3, 483.8 6 11.0, 512.6 6 21.3, 612.1 6 16.9, and 652...
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ژورنال
عنوان ژورنال: Pharmacogenomics
سال: 2014
ISSN: 1462-2416,1744-8042
DOI: 10.2217/pgs.14.39